Yes. They're at their most dangerous when making bargains, but even without that... they can poison their surroundings and corrupt the local wildlife, turning them into monsters.

[But even without that, their goal of chaos, and tendency to fall into the hands of those with power of some form meant that they were dangerous.]

But here is relatively safe, even if it's sterile.

[They've only had a handful of Incidents and none of those were from the orbs breaching containment.]