In the simulation? Only that there's supposed to be an orb here and that the drink might help.

[Natasha opted not to participate in that particular part of the training. She's been through a number of these programs and doesn't feel the need to throw herself into each opportunity anymore.

But then she's also been on several of the real missions. In light of which, she adds:]

When we're looking for the real orbs, it varies. We usually get a few leads, people of interest or local rumors.

Most of the clues come from interacting with the locals.